Boss Description
Tyreen Calypso is a ‘Boss’ in Borderlands 3. She is one of the two main antagonists and also the final boss of the game when she fuses with The Destroyer.
Tyreen the Destroyer is located in Destroyer’s Rift on the planet Pandora. The fast travel station will drop you in front of the battle arena next to 2 vending machines. 
You can farm Tyreen the Destroyer for these legendary weapons as it is the dedicated loot source for these items. Tyreen the Destroyer has a 15% legendary drop chance.
Tyreen the Destroyer Guide
Tyreen herself is the weak spot in this boss fight. Shoot at her when she appears from inside of the Destroyer.
Tyreen the Destroyer will throw a bunch of different projectiles at you, however, the one that looks like an Eridium rock can be punched back. This will stun her and you can go in and get free shots.
Standing right in front of the boss is kinda an unsafe spot, always be at a small angle.
When you dealt enough damage to Tyreen she will become immune and collapse onto the ground. Now you need to climb up her legs and deal damage at the top of her back. Some weapons are able to hit this critical spot from the ground. If done correctly, Tyreen will immerge from inside the Destroyer.
When Tyreen is getting at low health she will take flight and shoot fireballs and lasers at you.
A few Varkid will spawn during the fight. These initially aren’t much of a trouble unless they evolve. You can use them to score a second wind but don’t let them evolve too often.
