Targets of Opportunity is one of the Crew Challenges in Borderlands 3. You need to take out 10 mini-bosses in order to complete this challenge. These missions are given to you by the assassin called Zer0.
Each target has its own dedicated loot drops however once you defeated every one of them, Zer0 will reward you with the Lyuda. This powerful Legendary Sniper will then be waiting for you in the in-game mail. On top of that, you will unlock the “Zer0ed In” trophy/achievement upon completing the Targets of Opportunity Crew Challenge.
When you get close to one of the targets a prompt by Zer0 will be triggered. Also, an icon with two swords will appear on your map. If you managed to defeat the mini-boss the Icon will appear faded and they will be marked as dead on Zer0’s bounty board on Sanctuary III.
Hot Karl is hiding in a small COV camp north of Roland’s Rest. Turn left from the Fast Travel Station and make your way up the slopes. Keep to the side of the mountain and make your way across the container. Drop down and continue to follow the path.
Atomic & Sylestro are located on one of the outer edges of the map. You need to go through the jungle and into the Maliwan camp. At the crossroad in the camp, you want to go left and follow it all the way through. Atomic & Sylestro will spawn behind the big plant on the left.
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